Long Covid Land Toolbox
Neuroimmune pathophysiology of long COVID
Although COVID-19 was originally considered a respiratory illness, it is now well established that SARS-CoV-2 infection can have far-reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID-19 cases will go on to develop new or persistent long-term symptoms, a condition known in the literature as post-acute symptoms of COVID-19 (PASC) or by the patient-coined term Long COVID. Common neurological symptoms in Long COVID include new onset cognitive difficulties, dysautonomia, fatigue, and peripheral neuropathy. The emergence of Long COVID has prompted renewed interest in the study of post-acute infection syndromes (PAIS), particularly in the area of neuroimmune interactions. In this review we provide a comprehensive overview of the current body of literature on neurological manifestations of SARS-CoV-2 infection and Long COVID, with an emphasis on neuroimmune mechanisms drawn largely from autopsy studies and animal models. A more complete understanding of neuroimmune crosstalk in Long COVID will not only guide the development of therapies for this highly disabling condition but will also contribute to our general understanding of neuroimmune interactions in health and disease.
COVID-19 and the Auditory System – Five Years Later
Jun 23, 2025 | Auditory Processing Disorders, Tinnitus
A look at what we now know about how COVID-19 has been found to affect the auditory system, based on a review of the literature.
By Robert M. DiSogra, AuD
It has been five years since the COVID-19 pandemic started in the United States. Each of us has dealt with the impact of COVID-19 personally and professionally. In 2019, there were many unknowns about the virus’s effect on the many parts of the auditory system: hearing, tinnitus, balance, auditory processing, and cognition. Although it was tempting to make early declarations regarding the impact of COVID-19 on these areas, the aggregated peer-reviewed literature points to a more realistic picture.
This manuscript will summarize what we, as a profession, have learned about COVID-19 and its impact on the auditory system: hearing, balance, auditory processing, and cognition. Details can be found in the referenced literature.
Safety and Efficacy of Pemivibart, a Long-Acting Monoclonal Antibody, for Prevention of Symptomatic COVID-19: Interim Results From a Phase 3 Randomized Clinical Trial (CANOPY)
In September-November 2023, 306 participants received pemivibart (cohort A); 317 received pemivibart and 162 placebo (cohort B). The most common study drug-related adverse events were infusion-related reactions (cohort A: 11/306 [3.6%]; cohort B: 7/317 [2.2%, pemivibart] and 0/162 [placebo]). Four of 623 (0.6%) participants who received pemivibart experienced anaphylactic reactions (2 serious). In cohort A, the composite COVID-19 incidence through month 6 was 11/298 (3.7%; 2 deaths). In cohort B, 6/317 (1.9%; no deaths) and 19/160 (11.9%; no deaths) pemivibart and placebo participants, respectively, met the endpoint through month 6 (84.1% standardized relative risk reduction [RRR; 95% CI, 60.9-93.5; nominal P<.0001]), and 15/317 (4.7%; 1 death) and 29/160 (18.1%; no deaths) pemivibart and placebo participants, respectively, met the endpoint through month 12 (73.9% standardized RRR [95% CI, 52.8-85.6; nominal P<.0001]). Twelve month protection was conferred with no additional dosing.
Your Path Starts Here
What is Help for Long COVID?
Millions of people around the world are still struggling with the lingering effects of COVID-19. Unfortunately, most Care Providers do not understand or know how to diagnose or treat Long COVID patients. Help for Long COVID empowers Long COVID patients to find the help they need, discovering care providers who can treat them, and allowing patients to share their experiences and learn from the experiences of others. There is no cure for Long COVID, but help is available.
COVID LONG-HAULERS CANADA
Who Are Long-Haulers?
The Centers for Disease Control and Prevention has named this syndrome as post-acute sequelae of COVID-19 (PASC), and you will often see it called Long COVID or Post COVID Conditions. People living with these symptoms are sometimes referred to as COVID-19 long-haulers.
Long-haulers are individuals who still have persistent symptoms for 4 weeks or longer that are either continuous or arise weeks or months after initially recovering from COVID-19.
Many will suffer for months, and report prolonged, multisystem involvement and significant disability.
Still Masked, Still Right: A Data-Driven Case for Vigilance
Last Updated May 7, 2025
Fact Sheet Prepared by:
Sean P. Mullen, PhD
Associate Professor, Health and Kinesiology
Director, Exercise, Technology, and Cognition Lab
University of Illinois Urbana-Champaign
This brief was prepared to support patients who continue to take precautions against SARS-CoV-2 and/or report symptoms that may be downplayed. The evidence summarized below reflects current peer-reviewed science on the effects of SARS-CoV-2 on the brain, immune system, cardiovascular system, and overall functioning, even after mild or asymptomatic infection.
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1 in 5 men surveyed had erectile dysfunction up to 2 years after COVID
A total of 19.0% of 609 men who completed a survey in Japan and had persistent COVID symptoms reported erectile dysfunction (ED) 1 and/or 2 years post-infection, perhaps due to depression, anxiety, and/or sleep disturbances, suggest researchers with the COVID-19 Recovery Study II Group.
The group conducted a case-control study based on a survey fielded 1 and 2 years post-infection about ED and underlying factors among 609 men aged 20 years and older admitted to 1 of 20 hospitals for COVID-19 from March to September 2021, a period spanning the Alpha and Delta variants. The median participant age was 56 years.
“In COVID-19 patients, vascular endothelial damage due to inflammatory cytokines and hypoxia in the acute phase of COVID-19 lead to the progression of ED,” the investigators wrote. “Furthermore, ED is affected by physical stress and psychological stress.”
The findings were published in Scientific Reports.
90% of Long Covid cases come from a "mild" SARS-COV-2 acute infection
We strive to reduce the impact of airborne pollutants and infectious diseases by advocating for the widespread adoption of HEPA and MERV filtration systems, supporting mask usage without stigma, and disseminating reliable information about the long-term harm caused by COVID-19 and the effectiveness of clean air.