Long Covid Land Toolbox
Airfanta Space with Engineer Wong 3.0
November 22, 2025 Hosted by @cb_grl & @Dave_it_up
We demand action, not denial.
Turn research into care & treatment
Recognize and prepare the burdens of LongCOVID
Prevention is pivotal #COVIDisNotOver
“Nothing about us without us”: fair representation for all affected.
COVID-19 is “Airborne AIDS”: provocative oversimplification, emerging science, or something in between?
October 13, 2025
Highlights
Introduction: Why compare HIV and SARS-CoV-2?
Rising Burden of Paediatric Long COVID After Reinfection
October 26, 2025
Rising Burden of Paediatric Long COVID After Reinfection
The long-term impact of SARS-CoV-2 infection on children remains a pressing public health concern, particularly in the context of paediatric long COVID, also referred to as post-acute sequelae of SARS-CoV-2 infection (PASC). While early studies focused on initial infections, the effects of reinfection during the omicron era have been unclear. A large-scale retrospective cohort study, conducted through the Researching COVID to Enhance Recovery (RECOVER) Initiative, has now provided important insights into this issue by examining data from 40 children’s hospitals across the United States.
The study included 465,717 children and adolescents under 21 years of age who had a documented SARS-CoV-2 infection between January 2022 and October 2023. Of these, 58,417 (12.5%) experienced reinfection confirmed by PCR, antigen test, or clinical diagnosis at least 60 days after their first infection. Researchers compared rates of PASC diagnoses (U09.9) and 24 symptoms previously linked to long COVID between first and second infections, adjusting for demographic, clinical, and health utilisation factors.
Reinfection Doubles Risk of Long COVID and Multisystem Effects…
Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR):
a retrospective cohort study
Background
Findings
More than one-third of individuals with COVID-19 experience long COVID
September 17, 2025
A systematic review and meta-analysis published in Open Forum Infectious Diseases reported a pooled prevalence of long COVID as 36% worldwide.
The World Health Organization has defined long COVID as the continuation or development of COVID-19-related symptoms 3 months or longer after initial infection with SARS-CoV-2.
To consolidate data on the prevalence of long COVID, investigators from the University of Michigan and Yale School of Public Health in the United States searched publication databases for relevant studies through July 2024.
A total of 429 studies, representing over 2 million individuals with confirmed COVID-19, were included in the final analysis. The studies were conducted in Europe (n=195), Asia (n=126), North America (n=61), South America (n=31), Africa (n=9), Oceania (n=3), and multiple regions (n=4).
The pooled global prevalence of long COVID among individuals who had confirmed COVID-19 was 36% (95% CI, 33-40; P <.001; I2=100%). The investigators posited that the heterogenous definition of long COVID, study design, population characteristics, and the evolution of SARS-CoV-2 likely contributed to the high heterogeneity.
Postural orthostatic tachycardia syndrome in post-COVID-19 long-hauler patients is associated with platelet storage pool deficiency
Front. Med., 10 September 2025
Sec. Hematology
Postural orthostatic tachycardia syndrome (POTS), a type of dysautonomia, has been an enigma to many healthcare providers. As many as 80% of coronavirus disease 2019 (COVID-19) long-hauler patients meet the diagnostic criteria for POTS, highlighting awareness of this debilitating multisystem disorder. The etiology of POTS has not been entirely defined, but researchers have speculated that an immunological stressor such as a viral infection might be an initiating event. Prior to the pandemic, we reported that POTS patients have a bleeding diathesis with platelet dense granule storage pool deficiency (δ-SPD).
Published:
SARS-CoV-2 infection heightens the risk of developing HPV-related carcinoma in situ and cancer
Objective
This study aims to investigate the impact of SARS-CoV-2 infection on HPV-related cancer and carcinoma in situ.
Conclusion
SARS-CoV-2 infection is associated with elevated risks of HPV-related carcinoma in situ and cancer, irrespective of age or race. The findings underscore the importance of understanding the interplay between viral infections and cancer development, particularly in the context of the COVID-19 pandemic.